Complex coding and regulatory polymorphisms in a restriction factor determine the 1 susceptibility of Drosophila to viral infection
نویسندگان
چکیده
Complex coding and regulatory polymorphisms in a restriction factor determine the 1 susceptibility of Drosophila to viral infection 2 Chuan Cao , Rodrigo Cogni ⃰ , Vincent Barbier and Francis M. Jiggins ⃰ 3 ⃰ Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom. 4 CNRS, Institut de Biolosgie Moléculaire et Cellulaire, Strasbourg, France Faculté des 5 Sciences de la Vie, Université de Strasbourg, Strasbourg, France. 6 Current Address: Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, United 7 Kingdom 8 Current Address: Department of Ecology, University of São Paulo, São Paulo, 05508-900, 9 Brazil 10 Current Address: Institute for Immunology and Informatics, University of Rhode Island, 80 11 Washington St. Room 334B, Providence, RI 02903 12
منابع مشابه
Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility of Drosophila to Viral Infection
It is common to find that major-effect genes are an important cause of variation in susceptibility to infection. Here we have characterized natural variation in a gene called pastrel that explains over half of the genetic variance in susceptibility to the Drosophila C virus (DCV) in populations of Drosophila melanogaster We found extensive allelic heterogeneity, with a sample of seven alleles o...
متن کاملRegulatory effects of cis- and trans-LncRNAs on differential expression of genes following infection with viral hemorrhagic septicemia virus in rainbow trout (Oncorhynchus mykiss)
In this study the cis and trans regulatory effect of long non-coding genes (lncRNA) on the expression of genes in fish infected by Viral hemorrhagic septicemia virus (VHS) was investigated using RNA-seq technology. At the end of experimental period (the thirty fifth day), total RNA was extracted from spleen tissue (group treated with virus) and physiological serum (control group) was used to pr...
متن کاملGenetic Association of the Antiviral Restriction Factor TRIM5 with Human Immunodeficiency Virus Type 1 Infection
The innate antiviral factor TRIM5 restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to abortive infection. While overexpression of human TRIM5 results in modest restriction of human immunodeficiency virus type 1 (HIV-1), this inhibition is insufficient to block productive infection of human cells. We hypothesized that polymorphisms wit...
متن کاملGenetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.
The innate antiviral factor TRIM5alpha restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to abortive infection. While overexpression of human TRIM5alpha results in modest restriction of human immunodeficiency virus type 1 (HIV-1), this inhibition is insufficient to block productive infection of human cells. We hypothesized that polymor...
متن کاملPolymorphisms in Promoter Region of the Interferon - Gamma Receptor1 Gene and its Relation with Susceptibility to Brucellosis
Background & Objective: Brucellosis is one of the most prevalent bacterial zoonotic diseases which afflicts both humans and animals. Genetic factors play an important role in susceptibility to brucellosis. One of these factors is interferon-gamma (IFN-g), which is vital in the defense mechanism against infectious diseases such as brucellosis. The purpose of this study was to ev...
متن کامل